Into a shallow, wide bowl, place panko, paprika, garlic powder, onion powder, salt and pepper. Stir until thoroughly combined.
In another shallow bowl, whisk egg. Then whisk in milk, salt and pepper.
Lightly coat a medium-sized baking pan with cooking spray.
Dredge fish in egg mixture, gently shake off excess liquid and drop into panko mixture. Pat mixture onto all sides of the fish and gently place onto baking pan, handling carefully as not to loose the coating.