Southwest Tuna Macaroni and Cheese Casserole

READY IN: 40mins
Recipe by Stacky5

I made this recipe last night with things that I had on-hand, I must say that I had no leftovers -- from my kids to their friends, me and Pube....We all loved this! It's so easy that I'm a bit embarrassed to post...But it's one of our new favorites!

Top Review by Domestic Goddess

Editing my review: Today I made this delicious casserole, but I only had a can of cheddar cheese soup, so instead of adding a full soup can of milk, I added a half can of milk, plus a half can of a mild salsa, which worked well in this dish. I also used shredded Mexican cheese in place of sharp cheddar, and I topped the casserole with 3 tablespoons of bread crumbs.
My review posted on April 26, 2011: This was pretty good, but even bettter when reheated the next day. I had to use a can of Campbell's Fiesta Nacho Cheese Soup in place of the other, as Campbell's no longer makes the Southwest-Style Pepper Jack Soup, plus I used 2-(5 oz.) cans of the albacore tuna, since you can no longer find the 12-ounce cans. Since there was so much liquid to make this dish, I ended up adding 2-1/2 cups of the macaroni (which I used rotini). I did not add any salt, but did add 1/4 tsp of McCormick's Hot Shot! Seasoning in place of the pepper (it's a blend of black pepper & red pepper). I found I had to bake the casserole a bit longer (for 35 minutes). Next time I may bake it at 375 instead of 350, so the topping/the bread crumbs, will brown up a bit more.

Ingredients Nutrition


  1. Cook macaroni according to package directions to "al dente", then drain and rinse with cool water, and let drain again.
  2. Meanwhile, combine soup, mayonnaise and milk, and stir until smooth.
  3. Preheat oven to 350 degrees and slightly grease a 2 quart glass baking dish.
  4. Mix macaroni, soup mixture, cheddar cheese, salt & pepper, and flaked tuna thoroughly in a large bowl.
  5. Pour mixture into baking dish, sprinkle bread crumbs evenly on top, and then dot with margarine on top.
  6. Bake, uncovered at 350 degrees for 30 minutes.

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