Upside Down Pepperoni Pizza Casserole

"Fun and easy take on pepperoni pizza - one of my sons favorites. Great one-dish meal!"
photo by Lori Mama photo by Lori Mama
photo by Lori Mama
photo by Shelby Jo photo by Shelby Jo
photo by ksims86 photo by ksims86
photo by lha9310 photo by lha9310
photo by Shelby Jo photo by Shelby Jo
Ready In:


  • 1 - 1 12 lb ground beef
  • 1 medium onion, diced
  • 2 garlic cloves, minced
  • 1 (8 ounce) package mushrooms, sliced
  • 1 (4 ounce) can black olives, drained
  • 1 (15 ounce) can pizza sauce
  • 5 ounces turkey pepperoni, slices
  • 3 -4 ounces low fat mozzarella, shredded
  • 1 (16 1/3 ounce) package grands homestyle refrigerated reduced-fat buttermilk biscuits, separated and cut into fourths


  • Preheat oven to 400 degrees and prepare baking dish (I use a 1.75qt oval baker).
  • Over medium heat, combine the ground beef, onion and garlic in a large skillet until beef is browned.
  • Add the mushrooms, olives, pepperoni and tomato sauce and heat through.
  • Pour mixture into prepared baking dish.
  • Sprinkle with mozzarella cheese.
  • Top randomly with biscuit pieces.
  • Bake 15-18 minutes until biscuits are browned and casserole is bubbly.

Questions & Replies

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  1. mltarango
    YUM, YUM, YUM, delicious, the only change I made is that I put half the mixture in the dish, sprinkled cheese over, then put the rest of the meat mix over that, sprinkled with cheese and then put the biscuits. My husband said this is a keeper.
  2. Kristina W.
    My family loves this dish! I use croissant instead of biscuits and I brush on a little melted butter/garlic salt mixture on top. Always good served with a salad! ??
  3. lha9310
    This is an Excellent Recipe for the Dutch Oven.
  4. poarch0
    this was a big hit at my house. everyone loved it! its so quick and easy great for those really busy days.
  5. CyndeeF
    I made this for dinner last night. Everyone loved it! Even my picky eater went back for seconds. I like that this recipe can be changed so easily to fit what my family likes. This ia a keeper!


  1. Kerry G
    I made a few substitutes in the recipe: turkey instead of beef, garlic powder instead of fresh garlic, and spagetti sauce instead of pizza sauce. The saddest part, however, was that I had to make it without pepperoni because I forgot to buy some at the store. Despite the lack of pepperoni, this recipe was delicious. It may have been the dish I used, but there wasn't quite enough room for all of the biscuit dough (I had two left over). I cooked mine for about 15 mins, till the biscuits were just golden on top (they were still pretty doughy on the bottom, but I prefer them that way). Since there's only 2 of us in the house, I have plenty of leftovers for lunch- I'm sure it's just as good the 2nd go-round. Thank you for this tasty recipe.<br/><br/>**update** This recipe has become one of our favorites, and we've made it several times since. My husband even made it for a company food day, and it was gone in a matter of minutes. We both love it so much we fight over the leftovers. Defintiely a keeper!
  2. Christelpie
    I made this last night and it was teriffic!! I used italian sausage instead of ground beef and I also added green peppers. I omitted the mushrooms and olives, and this still was great!! It really did taste like pizza. My hubbie loved it, he even ate the leftovers for breakfast this morning. Thanks so much for posting. One question, the biscuits on the bottom never quite cook all the way through. Any ideas?? I leave it in for longer but then the tops sometimes get too "done?" Either way, I love this!
  3. jessymroberts
    Wow - what is not to love about this recipe? DELICIOUS! I used real pepperoni instead of turkey as it was what I had on hand, and regular mozzarella. Gooey and cheesy and I'm thinking about picking up the ingredients to make it again next time I go grocery shopping! Made for PRMR Tag Game!
  4. Kittencalrecipezazz
    well this was a winner according to my DS who is a lover of pizza, the biscuits is a wonderful change from pizza dough, I did a few amount adjustments and used bulk Italian sausage in place of ground beef, thanks for sharing Brooke!



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