In a medium size bowl, combine flour, cheese, onion powder, garlic powder, and cayenne powder.
Stir in mayonnaise and milk - just until moistened. Important: do not overstir.
Pour into well greased muffin tin until two-thirds full. Fill 12 muffin slots.
Bake in a 425 degree oven for 12-15 minutes or until light brown. (Good tip for any leftover biscuits - cut biscuits in half and turn down into melted butter in a skillet. Grill until golden brown. Good for breakfast.).