Chop the onion then mix all the ingredients for the meat portion together, uncooked. All the seasonings should be eyeballed in -- just use your own knowledge of what tastes your family likes. Not too much of the liquid smoke or Worcestershire, but give a good few shakes of each. This really adds flavor. Mix together the ketchup and brown sugar for the topping and set aside.
Bake at 350°F for 30 minutes. Pull out the meatloaf and drain the excess juice from the pan. Put on the topping and bake for another 30 minutes. This goes very well with cheesy potatoes! Also, the leftovers can be used as meatloaf sandwiches, yummy!