Preheat oven to 350°F Mix spices and sugar; set aside. Place bread on baking sheet. Cut circle in top of bread and remove bread center to make room for the wheel of brie.
Spread butter on bread; sprinkle with 2 teaspoons of the spice mixture. With knife, make 2-inch cuts at 1-inch intervals around edge of bread. Remove rind from Bie and place in bread. Sprinkle Brie with remaining spice mixture. Replace top of bread.
Bake 20-30 minutes. To serve, remove bread top and break into bite size pieces. Dip bread pieces in hot Brie.