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    You are in: Home / Community Forums / Gluten-free Diet / Celiac Disease / Wheat allergy vs. Gluten allergy
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    Wheat allergy vs. Gluten allergy

    Sally O'mally
    Thu Aug 03, 2006 7:19 pm
    Semi-Experienced "Sous Chef" Poster
    I just received my allergy testing results yesterday. I've been reading up on my two big allergies egg and wheat.

    My question is...... Is an allergy to wheat the same as an allergy to gluten?

    I have MANY of the accompanying issues associated with Celiac Disease.

    Thanks to anyone who can help me!

    Sally in Seattle
    Sat Aug 05, 2006 7:35 pm Groupie
    Hi Sally,

    An allergy to wheat is not the same as an allergy to gluten. You can be allergic to wheat specifically without being allergic to other gluten containing grains such as rye and barley. However, an allergy test will not pick up intolerances and sensitivities. The only way to test for most intolerances is to eliminate the suspect food from the diet to see if symptoms disappear.
    That said, if you have symptoms of celiac disease, have been tested for that (different to allergy testing) ? In the case of celiac testing you must be consuming gluten containg foods prior to testing.

    Here's an explanation of the differences between wheat allergy and celiac disease from

    What is the difference between Coeliac Disease & wheat Allergy?

    Although the precise cause of coeliac is unknown, T cells may play a central role. A T cell-mediated or Type 4 (Delayed Hypersensitivity Immune response) to gluten is likely to be the major cause of the gut lesions and increased permeability to gluten and other foods. T cells may react with tissue glutaminase (the principal component of the endomysium auto antigen) and set in motion a series of inflammatory events that results in the classical coeliac mucosal lesion. Wheat Allergy, on the other hand, is a Type 1 (Immediate Hypersensitivity Immune response) where wheat protein causing excessive production of IgE antibodies. These IgE antibodies sit on mast cells & when the intestine comes in contact with wheat, they bind to the IgE antibodies & cause the mast cell to release histamine & other mediators. These excessive IgE antibodies to wheat can be measured in the blood by doing a RAST or a Skin Prick Test. This is usually seen in an atopic individual & commonly associated with eczema. In wheat allergy the individual will only react to wheat, whereas in coeliac they react to all gluten-containing cereals such as wheat, oats, barley & rye.
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